Integrin alpha-1

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.[5]

ITGA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDsOMIM: 192968 MGI: 96599 HomoloGene: 57137 GeneCards: ITGA1
Orthologs
SpeciesHumanMouse
Entrez

3672

109700

Ensembl

ENSG00000213949

ENSMUSG00000042284

UniProt

P56199

Q3V3R4

RefSeq (mRNA)

NM_181501

NM_001033228

RefSeq (protein)

NP_852478

NP_001028400

Location (UCSC)Chr 5: 52.79 – 52.96 MbChr 13: 115.09 – 115.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.[6] It has been shown to affect the motility of T cells.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000213949 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042284 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gardner, Humphrey (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. 819: 21–39. doi:10.1007/978-94-017-9153-3_2. ISBN 978-94-017-9152-6. PMID 25023165.
  6. Reilly, Emma C.; Sportiello, Mike; Emo, Kris Lambert; Amitrano, Andrea M.; Jha, Rakshanda; Kumar, Ashwin B. R.; Laniewski, Nathan G.; Yang, Hongmei; Kim, Minsoo; Topham, David J. (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.
  7. Reilly, EC; Lambert Emo, K; Buckley, PM; Reilly, NS; Smith, I; Chaves, FA; Yang, H; Oakes, PW; Topham, DJ (2 June 2020). "T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12306–12314. doi:10.1073/pnas.1915681117. PMC 7275699. PMID 32439709.

Further reading



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