Integrin beta 5

ITGB5
Identifiers
Aliases	ITGB5, Integrin, beta 5, integrin subunit beta 5
External IDs	OMIM: 147561 MGI: 96614 HomoloGene: 20511 GeneCards: ITGB5
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	124,901,418 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	33,769,708 bp[2]
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; ascending aorta; ; pancreatic ductal cell; ; left coronary artery; ; metanephric glomerulus; ; popliteal artery; ; gallbladder; ; visceral pleura; ; subcutaneous adipose tissue;
	Top expressed in
	calvaria; ; ciliary body; ; molar; ; external carotid artery; ; stria vascularis; ; internal carotid artery; ; medullary collecting duct; ; belly cord; ; choroid plexus; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein binding; integrin binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; focal adhesion; receptor complex; plasma membrane; cell surface; integrin complex; phagocytic vesicle; integrin alphav-beta5 complex; extracellular exosome;
Biological process	muscle contraction; endodermal cell differentiation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; extracellular matrix organization; epithelial cell-cell adhesion; stress fiber assembly; cell adhesion; integrin-mediated signaling pathway; viral entry into host cell; cell-matrix adhesion; viral process; transforming growth factor beta receptor signaling pathway; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
	3693
	16419
	ENSG00000082781
	ENSMUSG00000022817
	P18084
	O70309
	NM_002213; NM_001354764; NM_001354765; NM_001354766
	NM_001145884; NM_010580
	NP_002204; NP_001341693; NP_001341694; NP_001341695
	NP_001139356; NP_034710; NP_001391992
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]

Interactions

Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]

References

GRCh38: Ensembl release 89: ENSG00000082781 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.
"Entrez Gene: ITGB5 integrin, beta 5".
Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
Zhang, Lu-yang; Guo, Qing; Guan, Ge-fei; Cheng, Wen; Cheng, Peng; Wu, An-hua (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.
Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216. S2CID 23712246.
Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin". J. Biol. Chem. 265 (19): 11008–13. doi:10.1016/S0021-9258(19)38549-7. PMID 1694173.
Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC 2289188. PMID 1918165.
Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit". EMBO J. 9 (5): 1561–8. doi:10.1002/j.1460-2075.1990.tb08275.x. PMC 551850. PMID 2328726.
Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. Bibcode:1990PNAS...87.5354S. doi:10.1073/pnas.87.14.5354. PMC 54322. PMID 2371275.
Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. doi:10.1242/jcs.105.1.101. PMID 7689573.
Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. PMID 8757599.
Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. doi:10.1242/jcs.111.4.425. PMID 9443892.
Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. doi:10.1042/bj3310631. PMC 1219398. PMID 9531507.
Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. PMID 10438928.
Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID 10537314.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654. S2CID 7535200.
Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.

External links

ITGB5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082781 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2211615-5] McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.

[entrez-6] "Entrez Gene: ITGB5 integrin, beta 5".

[pmid11927607-7] Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.

[pmid12769841-8] Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.

[pmid12356872-9] Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.

[10] Zhang, Lu-yang; Guo, Qing; Guan, Ge-fei; Cheng, Wen; Cheng, Peng; Wu, An-hua (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.

[pmid_=_24336069-11] Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.