BCL2L10

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.[5][6][7]

BCL2L10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B4S
Identifiers
Aliases	BCL2L10, BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10
External IDs	OMIM: 606910 MGI: 1330841 HomoloGene: 8396 GeneCards: BCL2L10
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 52,109,263 bp[1] End 52,112,775 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 75,255,040 bp[2] End 75,258,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver skin of abdomen right adrenal gland left adrenal gland kidney nucleus accumbens duodenum vagina putamen endometrium Top expressed in secondary oocyte meninges morula ovary cumulus cell white adipose tissue subcutaneous adipose tissue blastocyst skin of abdomen major salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding caspase binding protein homodimerization activity protein heterodimerization activity Cellular component nucleus integral component of membrane cytosol nuclear membrane mitochondrion membrane mitochondrial outer membrane Biological process apoptotic process regulation of apoptotic process negative regulation of apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process female gamete generation spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10017 12049 Ensembl ENSG00000137875 ENSMUSG00000032191 UniProt Q9HD36 Q9Z0F3 RefSeq (mRNA) NM_001306168 NM_020396 NM_013479 RefSeq (protein) NP_001293097 NP_065129 NP_038507 Location (UCSC) Chr 15: 52.11 – 52.11 Mb Chr 9: 75.26 – 75.26 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.[7]