BD1060

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.[1]

BD1060
Identifiers
  • N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H20Cl2N2
Molar mass287.23 g·mol−1
3D model (JSmol)
  • C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl
  • InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2
  • Key:KFLJZQLENAVFAL-UHFFFAOYSA-N

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.[1]

See also

References
  1. Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.