Tyrosine-protein kinase BLK

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.[5][6] It is of the Src family of tyrosine kinases.

BLK
Identifiers
AliasesBLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDsOMIM: 191305 MGI: 88169 HomoloGene: 1297 GeneCards: BLK
Orthologs
SpeciesHumanMouse
Entrez

640

12143

Ensembl

ENSG00000136573
ENSG00000285369

ENSMUSG00000014453

UniProt

P51451

P16277

RefSeq (mRNA)

NM_001715
NM_001330465

NM_007549

RefSeq (protein)

NP_001317394
NP_001706

NP_031575

Location (UCSC)Chr 8: 11.49 – 11.56 MbChr 14: 63.61 – 63.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.[7]

References

  1. ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014453 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
  6. "Entrez Gene: BLK B lymphoid tyrosine kinase".
  7. Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode:1999PNAS...96.9557O. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.

Further reading


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