Beta-peptidyl aminopeptidase
Beta-peptidyl aminopeptidase (EC 3.4.11.25, BapA) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleaves N-terminal beta-homoamino acids from peptides composed of 2 to 6 amino acids
| Beta-peptidyl aminopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.11.25 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphingosinicella xenopeptidilytica strain 3-2W4 could use beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu as only source of carbon and energy.
References
- Heck T, Limbach M, Geueke B, Zacharias M, Gardiner J, Kohler HP, Seebach D (December 2006). "Enzymatic degradation of beta- and mixed alpha,beta-oligopeptides". Chemistry & Biodiversity. 3 (12): 1325–48. doi:10.1002/cbdv.200690136. PMID 17193247. S2CID 38292191.
- Geueke B, Namoto K, Seebach D, Kohler HP (September 2005). "A novel beta-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic beta-tri- and beta-dipeptides". Journal of Bacteriology. 187 (17): 5910–7. doi:10.1128/jb.187.17.5910-5917.2005. PMC 1196161. PMID 16109932.
- Geueke B, Heck T, Limbach M, Nesatyy V, Seebach D, Kohler HP (December 2006). "Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta,alpha-oligopeptides". The FEBS Journal. 273 (23): 5261–72. doi:10.1111/j.1742-4658.2006.05519.x. PMID 17064315. S2CID 84167461.
- Heck T, Kohler HP, Limbach M, Flögel O, Seebach D, Geueke B (September 2007). "Enzyme-catalyzed formation of beta-peptides: beta-peptidyl aminopeptidases BapA and DmpA acting as beta-peptide-synthesizing enzymes". Chemistry & Biodiversity. 4 (9): 2016–30. doi:10.1002/cbdv.200790168. PMID 17886858. S2CID 85123861.
External links
- Beta-peptidyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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