Carboxypeptidase A2

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.[5][6][7]

CPA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPA2, carboxypeptidase A2
External IDsOMIM: 600688 MGI: 3617840 HomoloGene: 37541 GeneCards: CPA2
Orthologs
SpeciesHumanMouse
Entrez

1358

232680

Ensembl

ENSG00000158516

ENSMUSG00000071553

UniProt

P48052

Q504N0

RefSeq (mRNA)

NM_001869

NM_001024698

RefSeq (protein)

NP_001860

NP_001019869

Location (UCSC)Chr 7: 130.27 – 130.29 MbChr 6: 30.54 – 30.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000158516 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem. 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805.
  6. Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  7. "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: M14.002
  • Overview of all the structural information available in the PDB for UniProt: P48052 (Human Carboxypeptidase A2) at the PDBe-KB.


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