Butyrophilin, subfamily 2, member A2
Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.[5][6][7]
Function
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[7]
References
- GRCh38: Ensembl release 89: ENSG00000124508 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000053216 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Henry J, Miller MM, Pontarotti P (June 1999). "Structure and evolution of the extended B7 family". Immunology Today. 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID 10354554.
- Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (May 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Research. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
- "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".
Further reading
- Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A (July 2002). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane". Proteomics. 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID 12124930. S2CID 25710334.
- Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J (February 2001). "The cluster of BTN genes in the extended major histocompatibility complex". Genomics. 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID 11170752.
External links
- BTN2A2 human gene location in the UCSC Genome Browser.
- BTN2A2 human gene details in the UCSC Genome Browser.
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