Calpastatin

Calpastatin is a protein that in humans is encoded by the CAST gene.[5][6][7][8]

CAST
Identifiers
AliasesCAST, BS-17, PLACK, calpastatin
External IDsOMIM: 114090 MGI: 1098236 HomoloGene: 7658 GeneCards: CAST
Orthologs
SpeciesHumanMouse
Entrez

831

12380

Ensembl

ENSG00000153113

ENSMUSG00000021585

UniProt

P20810

P51125

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 5: 96.53 – 96.78 MbChr 13: 74.84 – 74.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1–4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000153113 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021585 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ma H, Yang HQ, Takano E, Lee WJ, Hatanaka M, Maki M (Sep 1993). "Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains". J Biochem. 113 (5): 591–9. doi:10.1093/oxfordjournals.jbchem.a124088. PMID 8340353.
  6. Averna M, De Tullio R, Capini P, Salamino F, Pontremoli S, Melloni E (Dec 2003). "Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis". Cell Mol Life Sci. 60 (12): 2669–78. doi:10.1007/s00018-003-3288-0. PMID 14685690. S2CID 23794801.
  7. Raynaud P, Jayat-Vignoles C, Laforet MP, Leveziel H, Amarger V (Apr 2005). "Four promoters direct expression of the calpastatin gene". Arch Biochem Biophys. 437 (1): 69–77. doi:10.1016/j.abb.2005.02.026. PMID 15820218.
  8. "Entrez Gene: CAST calpastatin".

Further reading
  • The MEROPS online database for peptidases and their inhibitors: LI27.001


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