CatSper1

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]

CATSPER1
Identifiers
AliasesCATSPER1, CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDsOMIM: 606389 MGI: 2179947 HomoloGene: 14207 GeneCards: CATSPER1
Orthologs
SpeciesHumanMouse
Entrez

117144

225865

Ensembl

ENSG00000175294

ENSMUSG00000038498

UniProt

Q8NEC5

Q91ZR5

RefSeq (mRNA)

NM_053054

NM_139301

RefSeq (protein)

NP_444282

NP_647462

Location (UCSC)Chr 11: 66.02 – 66.03 MbChr 19: 5.39 – 5.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000175294 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038498 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
  6. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. Bibcode:2001Natur.413..603R. doi:10.1038/35098027. PMC 8462998. PMID 11595941. S2CID 4424815.
  7. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
  8. "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  9. "Entrez Gene: CatSper1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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