HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.[5][6][7][8]

HCN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
External IDsOMIM: 602780 MGI: 1096392 HomoloGene: 32093 GeneCards: HCN1
Orthologs
SpeciesHumanMouse
Entrez

348980

15165

Ensembl

ENSG00000164588

ENSMUSG00000021730

UniProt

O60741

O88704

RefSeq (mRNA)

NM_021072

NM_010408

RefSeq (protein)

NP_066550

NP_034538

Location (UCSC)Chr 5: 45.25 – 45.7 MbChr 13: 117.74 – 118.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[8]

Tissue distribution

HCN1 channel expression is found in the sinoatrial node,[9][10] the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.[11][12][13][14][15]

Ligands

Interactions

HCN1 has been shown to interact with HCN2.[20][21]

Epilepsy

De novo mutations in HCN1 cause epilepsy.[22]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000164588 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021730 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Santoro B, Grant SG, Bartsch D, Kandel ER (December 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–14820. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  6. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–729. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
  7. Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–462. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
  8. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1".
  9. Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, et al. (January 2005). "Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart". The Journal of Physiology. 562 (Pt 1): 223–234. doi:10.1113/jphysiol.2004.074047. PMC 1665484. PMID 15498808.
  10. Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, et al. (July 1999). "Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues". Circulation Research. 85 (1): e1–e6. doi:10.1161/01.RES.85.1.e1. PMID 10400919.
  11. Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z (November 2002). "Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites". Nature Neuroscience. 5 (11): 1185–1193. doi:10.1038/nn962. PMID 12389030. S2CID 18132966.
  12. Milligan CJ, Edwards IJ, Deuchars J (April 2006). "HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata". Brain Research. 1081 (1): 79–91. doi:10.1016/j.brainres.2006.01.019. PMID 16503331. S2CID 30929772.
  13. Moosmang S, Biel M, Hofmann F, Ludwig A (1999). "Differential distribution of four hyperpolarization-activated cation channels in mouse brain". Biological Chemistry. 380 (7–8): 975–980. doi:10.1515/BC.1999.121. PMID 10494850. S2CID 22722872.
  14. Wells JE, Rowland KC, Proctor EK (September 2007). "Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth". International Endodontic Journal. 40 (9): 715–721. doi:10.1111/j.1365-2591.2007.01297.x. PMID 17645513.
  15. Santoro B, Grant SG, Bartsch D, Kandel ER (December 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–14820. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  16. Chen X, Shu S, Bayliss DA (January 2009). "HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine". The Journal of Neuroscience. 29 (3): 600–609. doi:10.1523/JNEUROSCI.3481-08.2009. PMC 2744993. PMID 19158287.
  17. Zhou C, Douglas JE, Kumar NN, Shu S, Bayliss DA, Chen X (April 2013). "Forebrain HCN1 channels contribute to hypnotic actions of ketamine". Anesthesiology. 118 (4): 785–795. doi:10.1097/ALN.0b013e318287b7c8. PMC 3605219. PMID 23377220.
  18. Bojak I, Day HC, Liley DT (2013). "Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions". Frontiers in Computational Neuroscience. 7: 22. doi:10.3389/fncom.2013.00022. PMC 3617565. PMID 23576979.
  19. Zhou C, Liang P, Liu J, Ke B, Wang X, Li F, et al. (September 2015). "HCN1 Channels Contribute to the Effects of Amnesia and Hypnosis but not Immobility of Volatile Anesthetics". Anesthesia and Analgesia. 121 (3): 661–666. doi:10.1213/ANE.0000000000000830. PMC 4544830. PMID 26287296.
  20. Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, et al. (October 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 278 (44): 43781–43786. doi:10.1074/jbc.M306958200. PMID 12928435.
  21. Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (August 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 277 (33): 29634–29642. doi:10.1074/jbc.M200504200. PMID 12034718.
  22. Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, et al. (June 2014). "De novo mutations in HCN1 cause early infantile epileptic encephalopathy" (PDF). Nature Genetics. 46 (6): 640–645. doi:10.1038/ng.2952. PMID 24747641. S2CID 861414.

Further reading
  • HCN1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: O60741 (Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: O88704 (Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1) at the PDBe-KB.

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