CKMT1B

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine kinase (ubiquitous mtCK or CKMT1).[5]

CKMT1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCKMT1B, CKMT, CKMT1, UMTCK, creatine kinase, mitochondrial 1B
External IDsOMIM: 123290 MGI: 99441 HomoloGene: 69058 GeneCards: CKMT1B
Orthologs
SpeciesHumanMouse
Entrez

1159

12716

Ensembl

ENSG00000237289

ENSMUSG00000000308

UniProt

P12532

P30275

RefSeq (mRNA)

NM_020990
NM_001375484

NM_009897
NM_001355069

RefSeq (protein)

NP_034027
NP_001341998

Location (UCSC)Chr 15: 43.59 – 43.6 MbChr 2: 121.19 – 121.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 (CKMT1A and CKMT1B (this gene)) have been identified which encode identical mitochondrial creatine kinase proteins.[5]

Clinical significance

Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000237289 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000308 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".

Further reading


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