Collagen, type IV, alpha 2

COL4A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LI1
Identifiers
Aliases	COL4A2, ICH, POREN2, collagen type IV alpha 2, collagen type IV alpha 2 chain, BSVD2
External IDs	OMIM: 120090 MGI: 88455 HomoloGene: 1390 GeneCards: COL4A2
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	110,513,209 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	11,499,287 bp[2]
RNA expression pattern
	Top expressed in
	saphenous vein; ; pericardium; ; visceral pleura; ; stromal cell of endometrium; ; urethra; ; right coronary artery; ; ascending aorta; ; left coronary artery; ; pylorus; ; cardia;
	Top expressed in
	left lung lobe; ; external carotid artery; ; internal carotid artery; ; ascending aorta; ; belly cord; ; aortic valve; ; ankle joint; ; vas deferens; ; uterus; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding; extracellular matrix structural constituent conferring tensile strength;
Cellular component	extracellular matrix; extracellular region; basement membrane; collagen; collagen type IV trimer; endoplasmic reticulum lumen; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	collagen catabolic process; negative regulation of angiogenesis; cellular response to transforming growth factor beta stimulus; extracellular matrix organization; endodermal cell differentiation; angiogenesis; transcription, DNA-templated; collagen-activated tyrosine kinase receptor signaling pathway; human ageing; response to activity;
	Sources:Amigo / QuickGO
Orthologs
	1284
	12827
	ENSG00000134871
	ENSMUSG00000031503
	P08572
	P08122
	NM_001846
	NM_009932
	NP_001837
	NP_034062
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.[5][6][7]

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.[7]

References

GRCh38: Ensembl release 89: ENSG00000134871 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031503 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes". J Biol Chem. 262 (19): 9231–8. doi:10.1016/S0021-9258(18)48071-4. PMID 2439508.
Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13". Proc Natl Acad Sci U S A. 84 (2): 512–6. doi:10.1073/pnas.84.2.512. PMC 304239. PMID 3025878.
"Entrez Gene: COL4A2 collagen, type IV, alpha 2".

Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein". Cell Adhes. Commun. 2 (3): 185–93. doi:10.3109/15419069409004436. PMID 7827955.
Ständer M, Naumann U, Wick W, Weller M (1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth". Cell Tissue Res. 296 (2): 221–7. doi:10.1007/s004410051283. PMID 10382266. S2CID 20282995.
Kurpakus Wheater M, Kernacki KA, Hazlett LD (1999). "Corneal cell proteins and ocular surface pathology". Biotechnic & Histochemistry. 74 (3): 146–59. doi:10.3109/10520299909047967. PMID 10416788.
Kalluri R, Sukhatme VP (2000). "Fibrosis and angiogenesis". Curr. Opin. Nephrol. Hypertens. 9 (4): 413–8. doi:10.1097/00041552-200007000-00013. PMID 10926178.
Ghebrehiwet B, Peerschke EI, Hong Y, et al. (1992). "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV". J. Leukoc. Biol. 51 (6): 546–56. doi:10.1002/jlb.51.6.546. PMID 1377218. S2CID 1214598.
Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.
Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 17281–4. doi:10.1016/S0021-9258(17)44900-3. PMID 2211625.
Hernandez MR, Igoe F, Neufeld AH (1986). "Extracellular matrix of the human optic nerve head". Am. J. Ophthalmol. 102 (2): 139–48. doi:10.1016/0002-9394(86)90134-0. PMID 2426947.
Siebold B, Deutzmann R, Kühn K (1988). "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen". Eur. J. Biochem. 176 (3): 617–24. doi:10.1111/j.1432-1033.1988.tb14321.x. PMID 2844531.
Pöschl E, Pollner R, Kühn K (1988). "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure". EMBO J. 7 (9): 2687–95. doi:10.1002/j.1460-2075.1988.tb03122.x. PMC 457057. PMID 2846280.
Murata K, Motayama T, Kotake C (1986). "Collagen types in various layers of the human aorta and their changes with the atherosclerotic process". Atherosclerosis. 60 (3): 251–62. doi:10.1016/0021-9150(86)90172-3. PMID 3089234.
Soininen R, Huotari M, Hostikka SL, et al. (1988). "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region". J. Biol. Chem. 263 (33): 17217–20. doi:10.1016/S0021-9258(19)77818-1. PMID 3182844.
Hostikka SL, Tryggvason K (1989). "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain". J. Biol. Chem. 263 (36): 19488–93. doi:10.1016/S0021-9258(19)77660-1. PMID 3198637.
Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain". Eur. J. Biochem. 172 (1): 35–42. doi:10.1111/j.1432-1033.1988.tb13852.x. PMID 3345760.
Hostikka SL, Kurkinen M, Tryggvason K (1987). "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region". FEBS Lett. 216 (2): 281–6. doi:10.1016/0014-5793(87)80706-8. PMID 3582677.
Killen PD, Francomano CA, Yamada Y, et al. (1988). "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2)". Hum. Genet. 77 (4): 318–24. doi:10.1007/BF00291418. PMID 3692475. S2CID 11387376.
Glant TT, Hadházy C, Mikecz K, Sipos A (1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II". Histochemistry. 82 (2): 149–58. doi:10.1007/bf00708199. PMID 3997552. S2CID 19401258.
Uscanga L, Kennedy RH, Stocker S, et al. (1984). "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas". Digestion. 30 (3): 158–64. doi:10.1159/000199100. PMID 6389236.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134871 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031503 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2439508-5] Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes". J Biol Chem. 262 (19): 9231–8. doi:10.1016/S0021-9258(18)48071-4. PMID 2439508.

[pmid3025878-6] Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13". Proc Natl Acad Sci U S A. 84 (2): 512–6. doi:10.1073/pnas.84.2.512. PMC 304239. PMID 3025878.

[entrez-7] "Entrez Gene: COL4A2 collagen, type IV, alpha 2".

Collagen, type IV, alpha 2

References

Further reading