CREB5

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.[5][6][7]

CREB5
Identifiers
AliasesCREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDsOMIM: 618262 MGI: 2443973 HomoloGene: 18215 GeneCards: CREB5
Orthologs
SpeciesHumanMouse
Entrez

9586

231991

Ensembl

ENSG00000146592

ENSMUSG00000053007

UniProt

Q02930

Q8K1L0

RefSeq (mRNA)

NM_001011666
NM_004904
NM_182898
NM_182899

NM_172728
NM_001327821

RefSeq (protein)

NP_001011666
NP_004895
NP_878901
NP_878902

NP_001314750
NP_766316

Location (UCSC)Chr 7: 28.3 – 28.83 MbChr 6: 53.26 – 53.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,[8] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000146592 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053007 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID 8378084.
  6. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. doi:10.1016/S0021-9258(18)53604-8. PMID 8440710.
  7. "Entrez Gene: CREB5 cAMP responsive element binding protein 5".
  8. Cumulated Index Medicus. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. 1993.

Further reading


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