CREB5

CREB5
Identifiers
Aliases	CREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDs	OMIM: 618262 MGI: 2443973 HomoloGene: 18215 GeneCards: CREB5
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	28,825,894 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	53,677,361 bp[2]
RNA expression pattern
	Top expressed in
	synovial joint; ; blood; ; corpus callosum; ; monocyte; ; inferior ganglion of vagus nerve; ; synovial membrane; ; internal globus pallidus; ; saphenous vein; ; sural nerve; ; endothelial cell;
	Top expressed in
	hand; ; ascending aorta; ; aortic valve; ; foot; ; hair follicle; ; external carotid artery; ; internal carotid artery; ; skin of abdomen; ; conjunctival fornix; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	extracellular exosome; nucleus;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9586
	231991
	ENSG00000146592
	ENSMUSG00000053007
	Q02930
	Q8K1L0
	NM_001011666; NM_004904; NM_182898; NM_182899
	NM_172728; NM_001327821
	NP_001011666; NP_004895; NP_878901; NP_878902
	NP_001314750; NP_766316
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.[5][6][7]

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,[8] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

GRCh38: Ensembl release 89: ENSG00000146592 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053007 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID 8378084.
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. doi:10.1016/S0021-9258(18)53604-8. PMID 8440710.
"Entrez Gene: CREB5 cAMP responsive element binding protein 5".
Cumulated Index Medicus. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. 1993.

External links

Human CREB5 genome location and CREB5 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146592 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053007 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8378084-5] Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID 8378084.

[pmid8440710-6] Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. doi:10.1016/S0021-9258(18)53604-8. PMID 8440710.

[entrez-7] "Entrez Gene: CREB5 cAMP responsive element binding protein 5".

[8] Cumulated Index Medicus. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. 1993.

CREB5

References

External links

Further reading