Calpain-6

Calpain-6 (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene.[5]

CAPN6
Identifiers
AliasesCAPN6, CANPX, CAPNX, CalpM, DJ914P14.1, calpain 6, calpamodulin
External IDsOMIM: 300146 MGI: 1100850 HomoloGene: 7252 GeneCards: CAPN6
Orthologs
SpeciesHumanMouse
Entrez

827

12338

Ensembl

ENSG00000077274

ENSMUSG00000067276

UniProt

Q9Y6Q1

O35646

RefSeq (mRNA)

NM_014289

NM_007603

RefSeq (protein)

NP_055104

NP_031629

Location (UCSC)Chr X: 111.25 – 111.27 MbChr X: 142.59 – 142.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. In the MEROPS protease enzyme classification system, they are members of clan CA (papain-like proteases).[6] The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks a critical catalytic triad residue in its active site (cysteine nucleophile mutated to lysine) and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

References

  1. GRCh38: Ensembl release 89: ENSG00000077274 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067276 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Calpain 6". National Center for Biotechnology Information. U.S. National Library of Medicine. Archived from the original on 18 November 2020. Retrieved 2013-03-05.
  6. "Summary for clan CA". MEROPS. Retrieved 20 December 2021.


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