CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.[5]

CEACAM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEACAM1, BGP, BGP1, BGPI, carcinoembryonic antigen related cell adhesion molecule 1, CEA cell adhesion molecule 1
External IDsOMIM: 109770 MGI: 1347246 HomoloGene: 128630 GeneCards: CEACAM1
Orthologs
SpeciesHumanMouse
Entrez

634

26367

Ensembl

ENSG00000079385

ENSMUSG00000054385

UniProt

P13688
Q3KRG8

Q925P2

RefSeq (mRNA)

NM_001113368
NM_001113369
NM_007543

RefSeq (protein)

NP_001106839
NP_001106840
NP_031569

Location (UCSC)Chr 19: 42.51 – 42.56 MbChr 7: 25.22 – 25.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.[5]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.[6]

Interactions

CEACAM1 has been shown to interact with PTPN11[7] and Annexin A2.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000079385 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054385 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)".
  6. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  7. Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (January 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". The Journal of Biological Chemistry. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848.
  8. Kirshner J, Schumann D, Shively JE (December 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". The Journal of Biological Chemistry. 278 (50): 50338–45. doi:10.1074/jbc.M309115200. PMID 14522961.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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