Ceramide cholinephosphotransferase
In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction
- CDP-choline + N-acylsphingosine CMP + sphingomyelin
| ceramide cholinephosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.3 | ||||||||
| CAS no. | 9026-14-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.
References
- Kennedy EP (1962). "Phosphorylcholine-glyceride transferase". Methods Enzymol. 5: 484–486. doi:10.1016/s0076-6879(62)05264-7.
- Sribney M, Kennedy EP (December 1958). "The enzymatic synthesis of sphingomyelin". The Journal of Biological Chemistry. 233 (6): 1315–22. PMID 13610834.
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