Choroid

There are two circulations of the eye: the retinal (in the retina) and uveal, supplied in humans by posterior ciliary arteries, originating from the ophthalmic artery (a branch of the internal carotid artery).[2] The arteries of the uveal circulation, supplying the uvea and outer and middle layers of the retina, are branches of the ophthalmic artery and enter the eyeball without passing with the optic nerve. The retinal circulation, on the other hand, derives its circulation from the central retinal artery, also a branch of the ophthalmic artery, but passing in conjunction with the optic nerve.[3] They branch in a segmental distribution to end arterioles and not anastomoses. This is clinically significant for diseases affecting choroidal blood supply. The macula responsible for central vision and the anterior part of the optic nerve are dependent on choroidal blood supply.[4] The structure of choroidal vessels can be revealed by optical coherence tomography, and blood flow can be revealed by Indocyanine green angiography, and laser Doppler imaging.[5]

Choroidal blood flow revealed with ICG-angiography (Spectralis, Heidelberg) and laser Doppler imaging[6]

Melanin, a dark colored pigment, helps the choroid limit uncontrolled reflection within the eye that would potentially result in the perception of confusing images.

In humans and most other primates, melanin occurs throughout the choroid. In albino humans, frequently melanin is absent and vision is low. In many animals, however, the partial absence of melanin contributes to superior night vision. In these animals, melanin is absent from a section of the choroid and within that section a layer of highly reflective tissue, the tapetum lucidum, helps to collect light by reflecting it in a controlled manner. The uncontrolled reflection of light from dark choroid produces the photographic red-eye effect on photos, whereas the controlled reflection of light from the tapetum lucidum produces eyeshine (see Tapetum lucidum).

The choroid was first described by Democritus (c. 460 – c. 370 BCE) around 400 BCE, calling it the "chitoon malista somphos" (more spongy tunic [than the sclera]).[8] Democritus likely saw the choroid from dissections of animal eyes.[9]

About 100 years later, Herophilos (c. 335 – 280 BCE) also described the choroid from his dissections on eyes of cadavers.[10][11]

Choroid is the most common site for metastasis in the eye due to its extensive vascular supply. The origin of the metastases are usually from breast cancer, lung cancer, gastrointestinal cancer, and kidney cancer. Bilateral choroidal metastases are usually due to breast cancer, while unilateral metastasis is due to lung cancer. Choroidal metastases should be differentiated from uveal melanoma, where the latter is a primary tumour arising from the choroid itself.[12]

• Chorioretinitis
• Uveitis

• 
  Schematic cross section of the human eye; choroid is shown in purple.
• 
  Laser Doppler imaging of retinal and choroidal blood flow
• 
  Iris, front view
• 
  The terminal portion of the optic nerve and its entrance into the eyeball, in horizontal section
• 
  The interior of the posterior half of the left eyeball
• 
  Structures of the eye labeled
• 
  This image shows another labeled view of the structures of the eye
• 
  Calf's eye dissected to expose the choroid: its tapetum lucidum is iridescent blue

• Histology image: 08008loa – Histology Learning System at Boston University