GJC1

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.[5][6]

GJC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGJC1, CX45, GJA7, gap junction protein gamma 1
External IDsOMIM: 608655 MGI: 95718 HomoloGene: 4016 GeneCards: GJC1
Orthologs
SpeciesHumanMouse
Entrez

10052

14615

Ensembl

ENSG00000182963

ENSMUSG00000034520

UniProt

P36383

P28229

RefSeq (mRNA)

NM_001080383
NM_005497

NM_001159382
NM_001159383
NM_008122
NM_001359040

RefSeq (protein)

NP_001073852
NP_005488

NP_001152854
NP_001152855
NP_032148
NP_001345969

Location (UCSC)Chr 17: 44.8 – 44.83 MbChr 11: 102.69 – 102.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000182963 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034520 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kanter HL, Saffitz JE, Beyer EC (Dec 1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J Mol Cell Cardiol. 26 (7): 861–8. doi:10.1006/jmcc.1994.1103. PMID 7966354.
  6. "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa".

Further reading


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