Cyclamide

Cyclamides are a class of oligopeptides produced by cyanobacteria algae strains such as Microcystis aeruginosa. Some of them can be toxic.

Chemical structure of aerucyclamide A, a prototypical cyclamide

Cyclamides are cyclopeptides with either six or eight amino acids, some of which are modified from the their natural proteinogenic form.[1] They are typically characterized by thiazole and oxazole rings which are thought to be cysteine and threonine derivatives, respectively.[1] Cyclamides are biosynthesized through ribosomic pathways.[2][3]

See also

References
  1. "Cyclamides – a wealth of different bioactivities". NaToxAq Toxin of the week. NaToxAq, University of Copenhagen. 29 October 2018.
  2. Ramsy Agha; Samuel Cirés; Lars Wörmer & Antonio Quesada (2013). "Limited Stability of Microcystins in Oligopeptide Compositions of Microcystis aeruginosa (Cyanobacteria): Implications in the Definition of Chemotypes". Toxins. 5 (6): 1089–1104. doi:10.3390/toxins5061089. PMC 3717771. PMID 23744054.
  3. Cyril Portmann; Judith F. Blom; Karl Gademann & Friedrich Jüttner (2008). "Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806". J. Nat. Prod. 71 (7): 1193–6. doi:10.1021/np800118g. PMID 18558743.
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