DMG-PEG 2000

DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines,[1] and in particular forms part forms part of the drug delivery system for the Moderna COVID-19 vaccine.[2]

DMG-PEG 2000
Names
IUPAC name
1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol
Other names
PEG-DMG
Identifiers
3D model (JSmol)
  • InChI=1S/C122H242O50/c1-4-6-8-10-12-14-16-18-20-22-24-26-121(123)171-119-120(172-122(124)27-25-23-21-19-17-15-13-11-9-7-5-2)118-170-117-116-169-115-114-168-113-112-167-111-110-166-109-108-165-107-106-164-105-104-163-103-102-162-101-100-161-99-98-160-97-96-159-95-94-158-93-92-157-91-90-156-89-88-155-87-86-154-85-84-153-83-82-152-81-80-151-79-78-150-77-76-149-75-74-148-73-72-147-71-70-146-69-68-145-67-66-144-65-64-143-63-62-142-61-60-141-59-58-140-57-56-139-55-54-138-53-52-137-51-50-136-49-48-135-47-46-134-45-44-133-43-42-132-41-40-131-39-38-130-37-36-129-35-34-128-33-32-127-31-30-126-29-28-125-3/h120H,4-119H2,1-3H3
    Key: NLDCRRFPGOSAHV-UHFFFAOYSA-N
  • O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
Properties
C122H242O50
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also
Moderna COVID-19 vaccine nanoparticle ingredients

References
  1. Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H (2018). "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin. 41 (8): 1291–1294. doi:10.1248/bpb.b18-00208. PMID 30068880.
  2. "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).
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