DPH5

Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.[5][6]

DPH5
Identifiers
AliasesDPH5, CGI-30, HSPC143, NPD015, AD-018, diphthamide biosynthesis 5
External IDsOMIM: 611075 MGI: 1916990 HomoloGene: 6471 GeneCards: DPH5
Orthologs
SpeciesHumanMouse
Entrez

51611

69740

Ensembl

ENSG00000117543

ENSMUSG00000033554

UniProt

Q9H2P9

Q9CWQ0

RefSeq (mRNA)

NM_001077394
NM_001077395
NM_015958

NM_027193

RefSeq (protein)

NP_001070862
NP_001070863
NP_057042

NP_081469

Location (UCSC)Chr 1: 100.99 – 101.03 MbChr 3: 115.89 – 115.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis.

The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000117543 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033554 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol. 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916.
  6. "Entrez Gene: DPH5 DPH5 homolog (S. cerevisiae)".

Further reading


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