DR1 (gene)

Protein Dr1 is a protein that in humans is encoded by the DR1 gene.[5][6][7]

DR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDR1, NC2, NC2-BETA, NC2B, down-regulator of transcription 1, NCB2
External IDsOMIM: 601482 MGI: 1100515 HomoloGene: 38809 GeneCards: DR1
Orthologs
SpeciesHumanMouse
Entrez

1810

13486

Ensembl

ENSG00000117505

ENSMUSG00000029265

UniProt

Q01658

Q91WV0

RefSeq (mRNA)

NM_001938

NM_026106

RefSeq (protein)

NP_001929

NP_080382

Location (UCSC)Chr 1: 93.35 – 93.37 MbChr 5: 108.42 – 108.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.[7]

Interactions

DR1 (gene) has been shown to interact with DRAP1.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000117505 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029265 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inostroza JA, Mermelstein FH, Ha I, Lane WS, Reinberg D (Sep 1992). "Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription". Cell. 70 (3): 477–89. doi:10.1016/0092-8674(92)90172-9. PMID 1339312.
  6. Purrello M, Di Pietro C, Rapisarda A, Viola A, Corsaro C, Motta S, Grzeschik KH, Sichel G (1996). "Genomic localization of the human gene encoding Dr1, a negative modulator of transcription of class II and class III genes". Cytogenetics and Cell Genetics. 75 (2–3): 186–9. doi:10.1159/000134479. PMID 9040789.
  7. "Entrez Gene: DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)".
  8. Yeung K, Kim S, Reinberg D (Jan 1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Mol. Cell. Biol. 17 (1): 36–45. doi:10.1128/MCB.17.1.36. PMC 231727. PMID 8972183.
  9. Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, Landsman D, Levitt P, Tempst P, Reinberg D (Apr 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.

Further reading


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