DRAP1

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.[5][6]

DRAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDRAP1, NC2-alpha, DR1 associated protein 1
External IDsOMIM: 602289 MGI: 1913806 HomoloGene: 4703 GeneCards: DRAP1
Orthologs
SpeciesHumanMouse
Entrez

10589

66556

Ensembl

ENSG00000175550

ENSMUSG00000024914

UniProt

Q14919

Q9D6N5

RefSeq (mRNA)

NM_006442

NM_001291080
NM_024176

RefSeq (protein)

NP_006433

NP_001278009
NP_077138

Location (UCSC)Chr 11: 65.92 – 65.92 MbChr 19: 5.47 – 5.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.[6]

Interactions

DRAP1 has been shown to interact with FOXH1[7] and DR1.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000175550 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024914 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, et al. (April 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes & Development. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.
  6. "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)".
  7. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, et al. (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. Bibcode:2002Sci...298.1996I. doi:10.1126/science.1073405. PMID 12471260. S2CID 22923124.
  8. Mermelstein F, Yeung K, Cao J, Inostroza JA, Erdjument-Bromage H, Eagelson K, et al. (April 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes & Development. 10 (8): 1033–48. doi:10.1101/gad.10.8.1033. PMID 8608938.
  9. Yeung K, Kim S, Reinberg D (January 1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Molecular and Cellular Biology. 17 (1): 36–45. doi:10.1128/MCB.17.1.36. PMC 231727. PMID 8972183.

Further reading


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