David Ballou

David P. Ballou is a professor emeritus of biological chemistry at the University of Michigan Medical School in the United States.[1] He is best known for his development of rapid-reaction techniques,[2] including stopped flow and rapid freeze-quench EPR methods,[3] as tools to study the mechanisms of enzymes containing flavin,[4] iron,[5] cobalamin, or pyridoxal phosphate cofactors. Many of these studies were performed in collaboration with other scientists, most often with colleagues at Michigan.[6]

David P. Ballou
Nationality American
Citizenship American
Alma materAntioch College
University of Michigan
Known forPresteady-state enzyme kinetics methods
SpouseJean Ballou[1]
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Michigan
Thesis (1971)
Doctoral advisorGraham Palmer
Other academic advisorsVince Massey
Minor J. Coon

Biography

David Ballou grew up in Connecticut.[2] He received a B.S. in chemistry from Antioch College in 1965. In 1971, he received a Ph.D. from the University of Michigan under the supervision of Graham Palmer. From 1971-1972, he was a postdoctoral fellow with Vincent Massey and Minor J. Coon at the University of Michigan. He has been a faculty member in the Department of Biological Chemistry at the University of Michigan Medical School since 1972. In 2007, Ballou became a Fellow of the American Association for the Advancement of Science in recognition of his discovery of enzyme intermediates that are involved in biological oxidation reactions.[7] His most cited paper, l, "Oxidative Protein Folding Is Driven by the Electron Transport System",[8] has been cited 311 times according to Google Scholar, and he has contributed to 25 papers having more than 0100 citations each.[9]

Books
  • Fundamental Laboratory Approaches for Biochemistry and Biotechnology (2nd Ed) (2009) by Alexander J. Ninfa, David P. Ballou, and Marilee Benore. Published by Wiley (ISBN 978-0470087664).

References
  1. "David Ballou, Ph.D." 12 August 2014. Archived from the original on 2017-07-03. Retrieved 2020-01-20.
  2. Cheng Z, Zhang J, Ballou DP, Williams CH Jr (2011). "Reactivity of Thioredoxin as a Protein Thiol-Disulfide Oxidoreductase". Chemical Reviews. 111 (9): 5768–5783. doi:10.1021/cr100006x. PMC 3212873. PMID 21793530.
  3. Ballou DP, Palmer GA (1974). "Practical rapid quenching instrument for the study of reaction mechanisms by electron paramagnetic resonance spectroscopy". Analytical Chemistry. 46 (9): 1248–1253. doi:10.1021/ac60345a034.
  4. Ballou DP, Entsch B, Cole LJ (2005). "Dynamics involved in catalysis by single-component and two-component flavin-dependent aromatic hydroxylases". Biochem. Biophys. Res. Commun. 338 (1): 590–598. doi:10.1016/j.bbrc.2005.09.081. PMID 16236251.
  5. Gassner GT, Ludwig ML, Gatti DL, Correll CC, Ballou DP (1995). "Structure and mechanism of the iron-sulfur flavoprotein phthalate dioxygenase reductase". FASEB Journal. 9 (14): 1411–1418. doi:10.1096/fasebj.9.14.7589982. hdl:2027.42/154520. PMID 7589982. S2CID 14787031.
  6. "DP Ballou at Pubmed". Retrieved 2013-10-31.
  7. "AAAS Welcomes Two from Medical School". Archived from the original on 2013-10-19. Retrieved 2013-10-27.
  8. Martin Bader, Wilson Muse, David P Ballou, Christian Gassner, James C.A Bardwell, "Oxidative Protein Folding Is Driven by the Electron Transport System", published in Cell Volume 98, Issue 2, p217–227, 23 July 1999
  9. "Google Scholar".
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