Thymidine monophosphate

Thymidine monophosphate (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA. It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar deoxyribose, and the nucleobase thymine. Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; nevertheless, its symbol often includes a "d" ("dTMP").[1] Dorland’s Illustrated Medical Dictionary[2] provides an explanation of the nomenclature variation at its entry for thymidine.

Thymidine monophosphate
Skeletal formula of thymidine monophosphate as an anion, single negative charge
Space-filling model of the thymidine monophosphate molecule as an anion, double negative charge
Names
IUPAC name
Thymidine monophosphate
Other names
5'-Thymidylic acid
Identifiers
3D model (JSmol)
Abbreviations dTMP
3916216
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2 ☒N
    Key: GYOZYWVXFNDGLU-UHFFFAOYSA-L ☒N
  • CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O
Properties
C10H15N2O8P
Molar mass 322.2085 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

As a substituent, it is called by the prefix thymidylyl-.

See also

References
  1. Coghill, Anne M.; Garson, Lorrin R., eds. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.
  2. Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.



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