Dihydrokainic acid

Dihydrokainic acid
Names
	IUPAC name (3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline
	Systematic IUPAC name (2S,3S,4R)-3-(2-Hydroxy-2-oxoethyl)-4-(propan-2-yl)pyrrolidine-2-carboxylic acid
	Other names Dihydrokainate; DHK
Identifiers
CAS Number	52497-36-6 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	84942
ChEBI	CHEBI:43562;
ChEMBL	ChEMBL279561;
ChemSpider	97018;
PubChem CID	107883;
UNII	MQ4LMC2HN5 ;
	InChI InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 Key: JQPDCKOQOOQUSC-OOZYFLPDSA-N;
	SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O;
Properties
Chemical formula	C10H17NO4
Molar mass	215.249 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H312, H332
Precautionary statements	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Dihydrokainic acid is an organic compound that contains two carboxylic acid functional groups, making it a dicarboxylic acid. It is an inhibitor of the GLT-1 glutamate transporter.[1]

References

Kawahara, K; Hosoya, R; Sato, H; Tanaka, M; Nakajima, T; Iwabuchi, S (2002). "Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures". Glia. 40 (3): 337–49. doi:10.1002/glia.10133. hdl:2115/5937. PMID 12420313. S2CID 14246291.

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