Diphosphate-purine nucleoside kinase

In enzymology, a diphosphate-purine nucleoside kinase (EC 2.7.1.143) is an enzyme that catalyzes the chemical reaction

diphosphate + a purine nucleoside phosphate + a purine mononucleotide
diphosphate-purine nucleoside kinase
Identifiers
EC no.2.7.1.143
CAS no.70356-41-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are diphosphate and purine nucleoside, whereas its two products are phosphate and purine mononucleotide.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is diphosphate:purine nucleoside phosphotransferase. This enzyme is also called pyrophosphate-purine nucleoside kinase.

References

    • Tryon VV, Pollack D (1984). "Purine metabolism in Acholeplasma laidlawii B: novel PPi-dependent nucleoside kinase activity". J. Bacteriol. 159 (1): 265–70. PMC 215623. PMID 6330034.
    • Tryon VV, Pollack JD (1985). "Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and dependence on guanylate salvage". Int. J. Syst. Bacteriol. 35: 497–501. doi:10.1099/00207713-35-4-497.


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