Diphosphoinositol-pentakisphosphate kinase

In enzymology, a diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown)
Diphosphoinositol-pentakisphosphate kinase
Identifiers
EC no.2.7.4.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 5-diphosphate pentakisphosphate, whereas its 3 products are ADP, 1D-myo-inositol bisdiphosphate tetrakisphosphate and (isomeric configuration unknown).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase. Other names in common use include PP-IP5 kinase, diphosphoinositol pentakisphosphate kinase, and ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase.

References

    • Shears SB, Ali N, Craxton A, Bembenek ME (1995). "Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo". J. Biol. Chem. 270 (18): 10489–97. doi:10.1074/jbc.270.18.10489. PMID 7737983.
    • Brocker M, Shears SB, Mayr GW. "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". Biochem. J. 327: 553–60. PMC 1218829. PMID 9359429.


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