Doogie Kameāloha, M.D.

• Peyton Elizabeth Lee as Lahela "Doogie" Kameāloha,[5] a 16-year-old University of Hawaii Medical School graduate. She is nicknamed "Doogie" because of the television show Doogie Howser, M.D.
• Emma Meisel as Steph Denisco,[5] Doogie's best friend. She has a crush on Doogie’s brother, Kai.
• Matt Sato as Kai Kameāloha,[5] Doogie's older brother. He has a crush on Doogie’s best friend, Steph, but doesn’t know how to express his feelings.
• Wes Tian as Brian Patrick Kameāloha,[5] Doogie's younger brother
• Jeffrey Bowyer-Chapman as Charles Zeller,[5] one of Doogie's colleagues at Oahu Health Medical Center
• Mapuana Makia as Noelani Nakayama,[5] another colleague of Doogie's at Oahu Health Medical Center
• Kathleen Rose Perkins as Dr. Clara Hannon,[5] Doogie's mother and the chief of medicine at Oahu Health Medical Center where Doogie works
• Jason Scott Lee as Benny Kameāloha,[5] Doogie's father and the owner of a food truck called Benny's Shave Ice and Flowers

• Ronny Chieng as Dr. Lee,[5] a heart surgeon at Oahu Health Medical Center[lower-alpha 1]
• Alex Aiono as Walter Taumata,[5] a local teenage surfer, in whom Doogie is romantically interested
• Andrew Tinpo Lee as Mr. Hsiao
• Milo Manheim as Nico (season 2),[7] Lahela's patient who has been in and out of hospitals due having acute lymphoblastic leukemia and new love interest

• Barry Bostwick as Will, a patient of Lahela's suffering from heart failure who passes away in the first episode. He is the first patient she loses and originally the only person allowed to call her Doogie.
• Randall Park as Dr. Choi, the chief of staff at Oahu Health Medical Center who leaving for another position with the Los Angeles Lakers
• Magic Johnson as Himself
• Margaret Cho as Frankie, a patient of Lahela's who has chronic renal failure and needs a new kidney
• Kylie Cantrall as Olivia, the captain of the "Royals" dance team
• Max Greenfield as Dr. Arthur Goldstein
• Alyson Hannigan as Dawn
• Daniel Dae Kim as Max Lee, the CEO of Oahu Health Medical Center
• Lexie Duncan as Blake
• Kimiko Glenn as Kayla

The review aggregator website Rotten Tomatoes reported a 92% approval rating with an average rating of 6.6/10, based on 13 critic reviews. The website's critics consensus reads, "With a winning cast and a great bedside manner, Doogie Kamealoha, M.D. pays homage to its predecessor while successfully carving its own charming path."[19] Metacritic gave the series a weighted average score of 75 out of 100 based on 5 critic reviews, indicating "generally favorable reviews".[20]

Daniel Fienberg of The Hollywood Reporter stated that the series serves as an example of how a franchise can be modernized across time, claiming it succeeds to provide a story that can appeal to the nostalgic audience of Doogie Howser, M.D. and still manages to be a good story that can stand on its own, while complimenting the performances of the cast.[21] Joel Keller of Decider claimed that the show manages to distinguish itself from Doogie Howser, M.D by creating its own identity, citing its gender-flipped lead character and the story sets in Hawaii, found the series funny and family-oriented, and praised the chemistry between the actors and their performances.[22] Caroline Framke of Variety described the show as a sweet, bright, and earnest Disney Channel sitcom.[23] Polly Conway of Common Sense Media rated the series 4 out of 5 stars, acclaimed the depiction of positive messages, citing compassion, courage, and teamwork, applauded the presence of positive role models, stating that Peyton Elizabeth Lee's character demonstrates sensitivity and consideration for the needs of other individuals, while complimenting the diversity of the cast members.[24]