Double-stranded uracil-DNA glycosylase

Double-stranded uracil-DNA glycosylase (EC 3.2.2.28, Mug, double-strand uracil-DNA glycosylase, Dug, dsUDG, double-stranded DNA specific UDG, dsDNA specific UDG, UdgB, G:T/U mismatch-specific DNA glycosylase, UDG) is an enzyme with systematic name uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing).[1][2][3] This enzyme catalyses a specific chemical reaction: it hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Double-stranded uracil-DNA glycosylase
Identifiers
EC no.3.2.2.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is not active on DNA containing a T/G mispair or single-stranded DNA.

References

  1. Barrett TE, Schärer OD, Savva R, Brown T, Jiricny J, Verdine GL, Pearl LH (December 1999). "Crystal structure of a thwarted mismatch glycosylase DNA repair complex". The EMBO Journal. 18 (23): 6599–609. doi:10.1093/emboj/18.23.6599. PMC 1171723. PMID 10581234.
  2. Sung JS, Mosbaugh DW (August 2000). "Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV". Biochemistry. 39 (33): 10224–35. doi:10.1021/bi0007066. PMID 10956012.
  3. Mokkapati SK, Fernández de Henestrosa AR, Bhagwat AS (September 2001). "Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells". Molecular Microbiology. 41 (5): 1101–11. doi:10.1046/j.1365-2958.2001.02559.x. PMID 11555290.


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