UDP-glucuronic acid dehydrogenase

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) (EC 1.1.1.305, UDP-GlcUA decarboxylase, ArnADH) is an enzyme with systematic name UDP-glucuronate:NAD+ oxidoreductase (decarboxylating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

UDP-glucuronate + NAD+ UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+
UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Identifiers
EC no.1.1.1.305
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).

References
  1. Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR (April 2005). "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose". The Journal of Biological Chemistry. 280 (14): 14154–67. doi:10.1074/jbc.M414265200. PMID 15695810.
  2. Gatzeva-Topalova PZ, May AP, Sousa MC (October 2004). "Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry. 43 (42): 13370–9. doi:10.1021/bi048551f. PMC 2680612. PMID 15491143.
  3. Williams GJ, Breazeale SD, Raetz CR, Naismith JH (June 2005). "Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". The Journal of Biological Chemistry. 280 (24): 23000–8. doi:10.1074/jbc.M501534200. PMC 3326539. PMID 15809294.
  4. Gatzeva-Topalova PZ, May AP, Sousa MC (June 2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure. 13 (6): 929–42. doi:10.1016/j.str.2005.03.018. PMC 2997725. PMID 15939024.
  5. Yan A, Guan Z, Raetz CR (December 2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of Biological Chemistry. 282 (49): 36077–89. doi:10.1074/jbc.M706172200. PMC 2613183. PMID 17928292.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.