UDP-N-acetylglucosamine diphosphorylase

In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate diphosphate + UDP-N-acetyl-D-glucosamine
UDP-N-acetylglucosamine diphosphorylase
N-acetyl glucosamine 1-phosphate uridyltransferase homotrimer, Mycobacterium tuberculosis
Identifiers
EC no.2.7.7.23
CAS no.9023-06-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are UTP and[N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine. This enzyme participates in aminosugars metabolism.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase.

References

    • Pattabiraman TN, Bachhawat BK (June 1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain". Biochimica et Biophysica Acta. 50: 129–34. doi:10.1016/0006-3002(61)91068-X. PMID 13733356.
    • Strominger JL, Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234 (7): 1822–1827. doi:10.1016/S0021-9258(18)69933-8. PMID 13672971.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.