EDC3

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.[5][6][7]

EDC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDsOMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3
Orthologs
SpeciesHumanMouse
Entrez

80153

353190

Ensembl

ENSG00000179151

ENSMUSG00000038957

UniProt

Q96F86

Q8K2D3

RefSeq (mRNA)

NM_001142443
NM_001142444
NM_025083
NM_001351378
NM_001351379

NM_153799

RefSeq (protein)

NP_001135915
NP_001135916
NP_079359
NP_001338307
NP_001338308

NP_722494

Location (UCSC)Chr 15: 74.63 – 74.7 MbChr 9: 57.62 – 57.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000179151 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038957 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett. 569 (1–3): 18–26. doi:10.1016/j.febslet.2004.03.126. PMID 15225602.
  6. Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res. 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID 17533573.
  7. "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)".

Further reading


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