Elaine Hsiao

Elaine Yih-Nien Hsiao is an American biologist who is Professor in Biological Sciences at University of California, Los Angeles.[2][3] Her research considers the microbes that impact human health.[4][5][6] She was a 2022 Laureate for the Blavatnik Awards for Young Scientists.[7][8]

Elaine Hsiao
Hsiao in 2014
Born
Elaine Yih-Nien Hsiao
Alma materUniversity of California, Los Angeles
California Institute of Technology
Scientific career
InstitutionsUniversity of California, Los Angeles
California Institute of Technology
ThesisBrain, Gut and Immune Interactions in Autism Spectrum Disorder (2013)
Doctoral advisorPaul Patterson[1]
Websitehsiao.science

Early life and education

Hsiao was an undergraduate student in microbiology at the University of California, Los Angeles. After graduating she moved to California Institute of Technology, where she focused on neurobiology in the laboratory of Paul Patterson. At CalTech, she studied the neuroimmune system, and the molecular mechanisms that underpin disorders in neurodevelopment.[1]

Research and career

Hsiao moved to the research groups of Rustem F. Ismagilov and Sarkis Mazmanian.[9] In 2015, Hsiao joined the UCLA Brain Research Institute as an assistant professor.[10] She was made an associate professor in 2020. Hsiao is interested in microbes and how they regulate brain development and behavior. These microbes impact the brain by serving as moderators for neurotransmitters and neuropeptides, and are involved with complicated neurological behaviors. Alterations in the levels of these neuro-active molecules are involved in autism and Parkinson's disease.

Hsiao investigated how the maternal microbiome impacts fetal brain development.[11] She found that depleting the microbioata of a maternal gut damaged fetal brain development, altering the specific genes which are switched on and how axons between neurons formed. She showed that there were fewer axons which connect the thalamus to the cortex, and gave rise to sensory impairments.[11]

In 2013, Hsiao delivered a TEDx talk on how microbes can alter brain function.[12]

Awards and honours
  • 2014 Forbes 30 Under 30[13]
  • 2015 Kavli Fellow of the National Academy of Sciences[14]
  • 2017 Life Sciences Excellence Award[15]
  • 2018 Ben Barres Early Career Acceleration Award[16]
  • 2018 New York Stem Cell Foundation Robertson Neuroscience Investigator[17]
  • 2019 UCLA Life Sciences Excellence Award – Excellence in Research, Assistant Professor[18]
  • 2021 Scialog Fellow[19]
  • 2022 New York Academy of Sciences (Takeda Pharmaceuticals) Innovators in Science Award in Gastroenterology[20]
  • 2022 Blavatnik National Awards for Young Scientists[7]

Selected publications

References
  1. Hsiao, Elaine Yih-Nien (2013). Brain, Gut and Immune Interactions in Autism Spectrum Disorder. caltech.edu (PhD thesis). doi:10.7907/DEVQ-1P16. OCLC 1014494786.
  2. Elaine Hsiao publications indexed by Google Scholar
  3. Elaine Hsiao publications from Europe PubMed Central
  4. Jessica M Yano; Kristie Yu; Gregory P Donaldson; et al. (1 April 2015). "Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis". Cell. 161 (2): 264–276. doi:10.1016/J.CELL.2015.02.047. ISSN 0092-8674. PMC 4393509. PMID 25860609. Wikidata Q35366986.
  5. Elaine Y Hsiao; Sara W McBride; Sophia Hsien; et al. (5 December 2013). "Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders". Cell. 155 (7): 1451–1463. doi:10.1016/J.CELL.2013.11.024. ISSN 0092-8674. PMC 3897394. PMID 24315484. Wikidata Q29617111.
  6. Thomas C Fung; Christine A Olson; Elaine Y Hsiao (16 January 2017). "Interactions between the microbiota, immune and nervous systems in health and disease". Nature Neuroscience. 20 (2): 145–155. doi:10.1038/NN.4476. ISSN 1097-6256. PMC 6960010. PMID 28092661. Wikidata Q39090621.
  7. "Winners of the 2022 Blavatnik National Awards for Young Scientists Announced | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2022-06-29.
  8. "Biologist Elaine Hsiao named Blavatnik National Awards Laureate". UCLA. Retrieved 2022-09-21.
  9. "Elaine Hsiao Lab at UCLA — About". hsiao.science. Retrieved 2022-06-29.
  10. Lloyd-Smith, James O.; Funk, Sebastian; McLean, Angela R.; Riley, Steven; Wood, James L.N. (March 2015). "Nine challenges in modelling the emergence of novel pathogens". Epidemics. 10: 35–39. doi:10.1016/j.epidem.2014.09.002. ISSN 1755-4365. PMC 4715032. PMID 25843380.
  11. "Guts and brains: How microbes in a mother's intestines affect fetal neurodevelopment". UCLA. Retrieved 2022-06-29.
  12. Mind-altering microbes: how the microbiome affects brain and behavior: Elaine Hsiao at TEDxCaltech, retrieved 2022-06-29
  13. Herper, Matthew. "30 Under 30: The Young Scientists And Entrepreneurs Discovering Our Future". Forbes. Retrieved 2022-06-29.
  14. "Elaine Hsiao". nasonline.org. Retrieved 2022-06-29.
  15. andrewtran (2017-04-24). "Congratulations to Professors Stephanie White and Elaine Hsiao for winning a 2017 Life Sciences Excellence Award". Integrative Biology and Physiology. Retrieved 2022-06-29.
  16. andrewtran (2018-12-06). "Assistant Professor Elaine Hsiao chosen for $2.5 million Ben Barres Early Career Acceleration Award: Featured in UCLA Newsroom". Integrative Biology and Physiology. Retrieved 2022-06-29.
  17. "Elaine Y. Hsiao, PhD". New York Stem Cell Foundation. Retrieved 2022-06-29.
  18. "Faculty Awards – Molecular Biology Institute". Retrieved 2022-06-29.
  19. Advancement, Research Corporation for Science. "Six Projects Win Funding in 1st year of Scialog: Microbiome, Neurobiology and Disease". Research Corporation for Science Advancement. Retrieved 2022-06-29.
  20. "Biologist Elaine Hsiao chosen for Innovators in Science Award". UCLA. Retrieved 2022-06-29.
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