Eleanor Stride

Eleanor Phoebe Jane Stride OBE FREng is a Professor of Biomaterials at St Catherine's College, Oxford. Stride engineers drug delivery systems using carefully designed microbubbles and studies how they can be used in diagnostics.

Eleanor Stride
Alma materUniversity College London
AwardsInstitution of Engineering and Technology Harvey Prize (2015) Philip Leverhulme Prize (2009)
Scientific career
InstitutionsUniversity College London
University of Oxford
Doctoral advisorNader Saffari

Education

Stride completed her Bachelor's degree in Mechanical Engineering and a PhD in the Ultrasonics group at University College London.[1][2] She had planned to work for Aston Martin.[3] Whilst there became interested in using ultrasound for imaging microbubbles, and was awarded a Royal Society Brian Mercer Innovation Feasibility Award.[1][4][5]

Research and career

Stride was awarded a Royal Academy of Engineering lectureship at University College London, where she explored ultrasound for drug delivery.[6] Microbubbles in the bloodstream created a strong ultrasound echo, which allows doctors to trace where the blood is flowing.[7] Whilst at University College London she collaborated with the Wellcome Collection.[8] She was awarded an Engineering and Physical Sciences Research Council Challenging Engineering Award in 2011.[9] That year she joined the Oxford Institute of Biomedical Engineering in 2011.[10] She is a Fellow at St Catherine's College, Oxford.[11] The award allowed her to develop new agents for targeted drug delivery, which allowed clinicians more control in transporting and releasing medical therapeutics.[9] Stride encapsulates deactivated drugs in 'carriers' which can be navigated around the body to a target.[6] She also explored how her novel agents interacted with cells and tissue.[9] Her research could be used to deliver chemotherapy.[12] She has several patents for the creation and imaging of microbubbles.[13][14] She created the spin-out company AtoCap.[15][16] AtoCap focussed on the treatment of chronic infections.[17]

Stride was appointed full Professor in 2014.[10] By using custom-designed magnetic arrays, the Stride group have managed to trap particles in tissue several centimetres deep.[18] She demonstrated that it is possible to load oxygen into microbubbles to improve Sonodynamic therapy.[19][20] She was made a Fellow of the Royal Academy of Engineering in 2017.[21]

Public engagement and diversity

In 2016 Stride was named one of the Top 50 Influential Women in Engineering.[10][22][23] She has appeared on BBC Radio 4.[24][25] She features on a number of YouTube videos with the Royal Institution.[26] She created a revision series with BBC bitesize.[27]

Awards

Stride was appointed Officer of the Order of the British Empire (OBE) in the 2021 New Year Honours for services to engineering.[32]

References
  1. "Professor Eleanor Stride — Institute of Biomedical Engineering". www.ibme.ox.ac.uk. Retrieved 3 July 2018.
  2. UCL (15 March 2010), Mini-lecture: The science of microbubbles (UCL), retrieved 3 July 2018
  3. HAVAS LYNX (20 June 2018), Episode 5: #LXAcademy Launch 2018, Professor Eleanor Stride - A Completely New Angle, retrieved 3 July 2018
  4. Stride, E.; Saffari, N. (2005). "Investigating the significance of multiple scattering in ultrasound contrast agent particle populations - IEEE Journals & Magazine" (PDF). IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 52 (12): 2332–45. doi:10.1109/TUFFC.2005.1563278. PMID 16463501. S2CID 26846678.
  5. "International Day of Women and Girls in Science". Oxford University. 9 February 2018. Retrieved 3 July 2018.
  6. "Interview: Eleanor Stride IET A F Harvey prize winner". 3 February 2015. Retrieved 3 July 2018.
  7. "Top Universities | Video Search Site". www.universityvideos.org. Retrieved 3 July 2018.
  8. "Eating, walking, stretching and bubbles". Wellcome Collection. Retrieved 3 July 2018.
  9. "Dr Eleanor Stride, University College London - EPSRC website". epsrc.ukri.org. Retrieved 3 July 2018.
  10. "Eleanor Stride | www.oxfordsparks.ox.ac.uk". www.oxfordsparks.ox.ac.uk. Retrieved 3 July 2018.
  11. "Why haven't we cured cancer? - IET Events". events.theiet.org. Retrieved 3 July 2018.
  12. "Dr Eleanor Stride — ERA Foundation". ERA Foundation. 26 November 2014. Retrieved 3 July 2018.
  13. Method and apparatus for generating bubbles, issue-date: 2017-01-20, retrieved 3 July 2018
  14. Beverage composition comprising nanoencapsulated oxygen, issue-date: 2016, retrieved 3 July 2018
  15. "Meet The Team - Atocap". Meet The Team - Atocap. Retrieved 3 July 2018.
  16. "Eleanor Stride — Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences". www.ndorms.ox.ac.uk. Retrieved 3 July 2018.
  17. Labbaf, Sheyda; Horsley, Harry; Chang, Ming-Wei; Stride, Eleanor; Malone-Lee, James; Edirisinghe, Mohan; Rohn, Jennifer L. (6 December 2013). "An encapsulated drug delivery system for recalcitrant urinary tract infection". Journal of the Royal Society Interface. 10 (89): 20130747. doi:10.1098/rsif.2013.0747. ISSN 1742-5689. PMC 3808553. PMID 24068180.
  18. Barnsley, Lester C.; Carugo, Dario; Owen, Joshua; Stride, Eleanor (7 November 2015). "Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications". Physics in Medicine and Biology. 60 (21): 8303–8327. Bibcode:2015PMB....60.8303B. doi:10.1088/0031-9155/60/21/8303. ISSN 1361-6560. PMID 26458056. S2CID 29807333.
  19. McEwan, Conor; Owen, Joshua; Stride, Eleanor; Fowley, Colin; Nesbitt, Heather; Cochrane, David; Coussios, Constantin C.; Borden, M.; Nomikou, Nikolitsa (10 April 2015). "Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours". Journal of Controlled Release. 203: 51–56. doi:10.1016/j.jconrel.2015.02.004. ISSN 1873-4995. PMID 25660073.
  20. McEwan, Conor; Kamila, Sukanta; Owen, Joshua; Nesbitt, Heather; Callan, Bridgeen; Borden, Mark; Nomikou, Nikolitsa; Hamoudi, Rifat A.; Taylor, Mark A. (February 2016). "Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle". Biomaterials. 80: 20–32. doi:10.1016/j.biomaterials.2015.11.033. ISSN 1878-5905. PMID 26702983.
  21. "Professor of Engineering Science, University of Oxford". Royal Academy of Engineering. Retrieved 3 June 2018.
  22. "June 2016 - Professor Eleanor Stride makes top 50 Women in Engineering List — Institute of Biomedical Engineering". www.ibme.ox.ac.uk. Retrieved 3 July 2018.
  23. "Professor Eleanor Stride named as one of the top 50 women in Engineering | www.stcatz.ox.ac.uk". www.stcatz.ox.ac.uk. Retrieved 3 July 2018.
  24. "Nano-bubbles and drug delivery, The Imagineers - BBC Two". BBC. Retrieved 3 July 2018.
  25. "Woman's Hour - Five things we learnt about women in engineering from Professor Dame Ann Dowling - BBC Radio 4". BBC. Retrieved 3 July 2018.
  26. The Royal Institution (15 April 2014), Born to Engineer - Biomedical bubbles with Eleanor Stride, retrieved 3 July 2018
  27. "BBC Bitesize - Higher Engineering science - Nano-bubbles and drug delivery". BBC Bitesize. Retrieved 3 July 2018.
  28. "The promise of microbubbles". www.ucl.ac.uk. 16 March 2010. Retrieved 3 July 2018.
  29. "Acoustical Society of America Awards - Acoustical Society of America". Acoustical Society of America. Retrieved 3 July 2018.
  30. "Dr Eleanor Stride receives 2013 R. Bruce Lindsay Award of the Acoustical Society of America — Department of Engineering Science". www.eng.ox.ac.uk. Retrieved 3 July 2018.
  31. IET (25 February 2015), Professor Eleanor Stride: 2014 IET A.F. Harvey Prize Winner, retrieved 3 July 2018
  32. "No. 63218". The London Gazette (Supplement). 31 December 2020. p. N14.
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