EBI3

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[5][6]

EBI3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDsOMIM: 605816 MGI: 1354171 HomoloGene: 4207 GeneCards: EBI3
Orthologs
SpeciesHumanMouse
Entrez

10148

50498

Ensembl

ENSG00000105246

ENSMUSG00000003206

UniProt

Q14213

O35228

RefSeq (mRNA)

NM_005755

NM_015766

RefSeq (protein)

NP_005746

NP_056581

Location (UCSC)Chr 19: 4.23 – 4.24 MbChr 17: 56.26 – 56.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[7]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[7][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000105246 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003206 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".
  6. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.
  7. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID 18033300. S2CID 4425281.
  8. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. S2CID 32503719.
  9. Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423.

Further reading


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