Estradiol 17alpha-dehydrogenase
In enzymology, an estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is an enzyme that catalyzes the chemical reaction
- estradiol-17alpha + NAD(P)+ estrone + NAD(P)H + H+
estradiol 17-alpha-dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.148 | ||||||||
CAS no. | 9044-91-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The three substrates of this enzyme are estradiol-17alpha, NAD+, and NADP+, whereas its four products are estrone, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase. Other names in common use include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid oxidoreductase, and estradiol 17alpha-oxidoreductase. This enzyme participates in androgen and estrogen metabolism.
References
- Renwick AG, Engel LL (1967). "The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken liver". Biochim. Biophys. Acta. 146 (2): 336–48. doi:10.1016/0005-2744(67)90220-3. PMID 4383682.