EZH1

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.[5][6]

EZH1
Identifiers
AliasesEZH1, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
External IDsOMIM: 601674 MGI: 1097695 HomoloGene: 20458 GeneCards: EZH1
Orthologs
SpeciesHumanMouse
Entrez

2145

14055

Ensembl

ENSG00000108799

ENSMUSG00000006920

UniProt

Q92800

P70351

RefSeq (mRNA)

NM_001991
NM_001321079
NM_001321081
NM_001321082

NM_007970

RefSeq (protein)

NP_001308008
NP_001308010
NP_001308011
NP_001982

Location (UCSC)Chr 17: 42.7 – 42.75 MbChr 11: 101.08 – 101.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.[7] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.[8]


References

  1. GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (Feb 1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387.
  6. "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)".
  7. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E (Mar 2011). "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair". Genes Dev. 25 (5): 485–98. doi:10.1101/gad.2019811. PMC 3049289. PMID 21317239.
  8. Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH (Nov 2008). "EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency". Mol Cell. 32 (4): 491–502. doi:10.1016/j.molcel.2008.10.016. PMC 2630502. PMID 19026780.

Further reading


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