Fibroblast growth factor receptor-like 1

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.[5]

FGFRL1
Identifiers
AliasesFGFRL1, FGFR5, FHFR, fibroblast growth factor receptor-like 1, fibroblast growth factor receptor like 1, FGFR-5
External IDsOMIM: 605830 MGI: 2150920 HomoloGene: 11067 GeneCards: FGFRL1
Orthologs
SpeciesHumanMouse
Entrez

53834

116701

Ensembl

ENSG00000127418

ENSMUSG00000008090

UniProt

Q8N441

Q91V87

RefSeq (mRNA)

NM_001004356
NM_001004358
NM_021923
NM_001370296
NM_017862

NM_001164259
NM_054071

RefSeq (protein)

NP_001004356
NP_001004358
NP_068742
NP_001357225
NP_001004356.1

NP_001157731
NP_473412

Location (UCSC)Chr 4: 1.01 – 1.03 MbChr 5: 108.84 – 108.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.[5]

Transgenic mice expressing the giraffe ortholog of FGFRL1 are resistant against hypertension induced by angiotensin II.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".
  6. Liu C, Gao J, Cui X, Li Z, Chen L, Yuan Y, et al. (March 2021). "A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe". Science Advances. 7 (12). doi:10.1126/sciadv.abe9459. PMC 7968835. PMID 33731352.

Further reading


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