FKBP2

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[5][6]

FKBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFKBP2, FKBP-13, PPIase, FK506 binding protein 2, FKBP prolyl isomerase 2, FKBP13
External IDsOMIM: 186946 MGI: 95542 HomoloGene: 40604 GeneCards: FKBP2
Orthologs
SpeciesHumanMouse
Entrez

2286

14227

Ensembl

ENSG00000173486

ENSMUSG00000056629

UniProt

P26885

P45878

RefSeq (mRNA)

NM_001135208
NM_004470
NM_057092

NM_001166368
NM_008020
NM_001360286
NM_001360288

RefSeq (protein)

NP_001128680
NP_004461
NP_476433

NP_001159840
NP_032046
NP_001347215
NP_001347217

Location (UCSC)Chr 11: 64.24 – 64.24 MbChr 19: 6.96 – 6.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[6]

Interactions

FKBP2 has been shown to interact with ARFGEF1[7] and EPB41L2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000173486 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056629 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ (Sep 1991). "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6677–81. Bibcode:1991PNAS...88.6677J. doi:10.1073/pnas.88.15.6677. PMC 52151. PMID 1713687.
  6. "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa".
  7. Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. Bibcode:2003PNAS..100.2322P. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707.
  8. Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH (Apr 1998). "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". J. Cell Biol. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554.

Further reading


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