Fyn-related kinase

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[5][6]

FRK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDsOMIM: 606573 MGI: 103265 HomoloGene: 48065 GeneCards: FRK
Orthologs
SpeciesHumanMouse
Entrez

2444

14302

Ensembl

ENSG00000111816

ENSMUSG00000019779

UniProt

P42685

Q922K9

RefSeq (mRNA)

NM_002031

NM_001159544
NM_010237
NM_001358769

RefSeq (protein)

NP_002022

NP_001153016
NP_034367
NP_001345698

Location (UCSC)Chr 6: 115.93 – 116.06 MbChr 10: 34.36 – 34.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[6]

Interactions

FRK has been shown to interact with retinoblastoma protein.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
  6. "Entrez Gene: FRK fyn-related kinase".
  7. Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Further reading


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