FSCN1

Fascin is a protein that in humans is encoded by the FSCN1 gene.[5][6][7]

FSCN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDsOMIM: 602689 MGI: 1352745 HomoloGene: 48164 GeneCards: FSCN1
Orthologs
SpeciesHumanMouse
Entrez

6624

14086

Ensembl

ENSG00000075618

ENSMUSG00000029581

UniProt

Q16658

Q61553

RefSeq (mRNA)

NM_003088

NM_007984

RefSeq (protein)

NP_003079

NP_032010

Location (UCSC)Chr 7: 5.59 – 5.61 MbChr 5: 142.95 – 142.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor[8] and PKC alpha.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000075618 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029581 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
  6. Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
  7. "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
  8. Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270.
  9. Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Further reading


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