Dimethylallyltranstransferase

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).[5][6]

FDPS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFDPS, FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDsOMIM: 134629 MGI: 104888 HomoloGene: 1519 GeneCards: FDPS
EC number2.5.1.1
Orthologs
SpeciesHumanMouse
Entrez

2224

110196

Ensembl

ENSG00000160752

ENSMUSG00000059743

UniProt

P14324

Q920E5

RefSeq (mRNA)

NM_001253751
NM_134469
NM_180985

RefSeq (protein)

NP_001240680
NP_608219

Location (UCSC)Chr 1: 155.31 – 155.32 MbChr 3: 89 – 89.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Dimethylallyltranstransferase
Identifiers
EC no.2.5.1.1
CAS no.9032-79-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
SymbolFDPS
NCBI gene2224
HGNC3631
OMIM134629
RefSeqNM_002004
UniProtP14324
Other data
EC number2.5.1.1
LocusChr. 1 q22
Search for
StructuresSwiss-model
DomainsInterPro

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000160752 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059743 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.
  6. Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.


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