FCGR2A

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[5][6]

FCGR2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDsOMIM: 146790 MGI: 95500 HomoloGene: 47936 GeneCards: FCGR2A
Orthologs
SpeciesHumanMouse
Entrez

2212

14131

Ensembl

ENSG00000143226

ENSMUSG00000059498

UniProt

P12318

P08508

RefSeq (mRNA)

NM_001136219
NM_021642
NM_001375296
NM_001375297

NM_010188
NM_001356511

RefSeq (protein)

NP_001129691
NP_067674
NP_001362225
NP_001362226

n/a

Location (UCSC)Chr 1: 161.51 – 161.52 MbChr 1: 170.88 – 170.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

FCGR2A has been shown to interact with PIK3R1[7][8] and Syk.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000143226 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059498 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
  6. "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
  7. Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
  8. Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
  9. Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Further reading


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