FCGR3B

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.[5]

FCGR3B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb, Fc fragment of IgG receptor IIIb, CD16A, FCGR3A, Fc gamma receptor IIIb, CD16-I
External IDsOMIM: 610665 MGI: 2179523 HomoloGene: 477 GeneCards: FCGR3B
Orthologs
SpeciesHumanMouse
Entrez

2215

246256

Ensembl

ENSG00000162747

ENSMUSG00000059089

UniProt

O75015

A0A0B4J1G0

RefSeq (mRNA)

NM_001271037
NM_000570
NM_001244753
NM_001271035
NM_001271036

NM_144559
NM_180961

RefSeq (protein)

NP_000561
NP_001231682
NP_001257964
NP_001257965
NP_001257966

NP_653142

Location (UCSC)Chr 1: 161.62 – 161.63 MbChr 1: 170.85 – 170.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000162747 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059089 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)".
  6. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT (Feb 2006). "Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans". Nature. 439 (7078): 851–5. Bibcode:2006Natur.439..851A. doi:10.1038/nature04489. PMID 16482158. S2CID 4421459.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O75015 (Low affinity immunoglobulin gamma Fc region receptor III-B) at the PDBe-KB.


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