FCGR1A

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.[5][6][7]

FCGR1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDsOMIM: 146760 MGI: 95498 HomoloGene: 475 GeneCards: FCGR1A
Orthologs
SpeciesHumanMouse
Entrez

2209

14129

Ensembl

ENSG00000150337

ENSMUSG00000015947

UniProt

P12314

P26151

RefSeq (mRNA)

NM_000566

NM_010186

RefSeq (protein)

NP_034316

Location (UCSC)Chr 1: 149.78 – 149.79 MbChr 3: 96.19 – 96.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000150337 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015947 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics. 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
  6. Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics. 82 (1–2): 71–4. doi:10.1159/000015067. PMID 9763663. S2CID 20290009.
  7. "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
  8. The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P12314 (Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)) at the PDBe-KB.


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