Fructosamine-3-kinase

Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene.[5][6][7]

FN3K
Identifiers
AliasesFN3K, fructosamine 3 kinase
External IDsOMIM: 608425 MGI: 1926834 HomoloGene: 23336 GeneCards: FN3K
Orthologs
SpeciesHumanMouse
Entrez

64122

63828

Ensembl

ENSG00000167363

ENSMUSG00000025175

UniProt

Q9H479

Q9ER35

RefSeq (mRNA)

NM_022158

NM_001038699
NM_022014

RefSeq (protein)

NP_071441

NP_001033788
NP_071297

Location (UCSC)Chr 17: 82.74 – 82.75 MbChr 11: 121.33 – 121.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins.[7][8]

FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound identified in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of 3-deoxyglucosone (3DG). 3DG contributes to diabetic complications. Treatment of normal and diabetic rats with an inhibitor of FN3K demonstrated a large reduction (~50%) in systemic 3DG in both groups. Removal of 3DG at its source by inhibition of FN3K is a viable option to treat diabetes related diseases since it would require a much smaller dose of drug.

References

  1. GRCh38: Ensembl release 89: ENSG00000167363 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025175 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Szwergold BS, Howell S, Beisswenger PJ (Aug 2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes. 50 (9): 2139–47. doi:10.2337/diabetes.50.9.2139. PMID 11522682.
  6. Delpierre G, Van Schaftingen E (Dec 2003). "Fructosamine 3-kinase, an enzyme involved in protein deglycation". Biochem Soc Trans. 31 (Pt 6): 1354–7. doi:10.1042/BST0311354. PMID 14641062.
  7. "Entrez Gene: FN3K fructosamine 3 kinase".
  8. Delpierre G, Collard F, Fortpied J, Van Schaftingen E (August 2002). "Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes". Biochem. J. 365 (Pt 3): 801–8. doi:10.1042/BJ20020325. PMC 1222720. PMID 11975663.

Further reading

See also


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