Gösta Pettersson (biochemist)

Gösta Pettersson is an emeritus professor in biochemistry at Lund University, Sweden. He was born in 1937 in Varberg, Sweden. He gained his Ph.D. at Lund University in 1966 on the basis of a thesis on toluquinones (natural products),[1] and his early research was mainly concerned with fumigatin and other products of fungal metabolism.[2][3][4]

Gösta Pettersson
Born (1937-11-24) 24 November 1937
Varberg, Halland County, Sweden
EducationLund University (Ph.D. 1966)
Known forAlcohol dehydrogenase
ChildrenUlf Ryde-Pettersson
Scientific career
FieldsBiochemistry (especially kinetics)
InstitutionsLund University, Sweden
ThesisStudies on the biosynthesis of fungal toluquinones (1966)

The turning point in Pettersson's career came in the wake of a kinetic study of an enzyme from Aspergillus fumigatus.[5] This paper has had virtually no influence on the progress of biochemistry, having never been cited in half a century except for once by its author, but it marked the beginning of the work on enzymes and kinetics for which Pettersson is best known.

Alcohol dehydrogenase

The major experimental focus of Pettersson's work on the kinetics of enzyme-catalysed reactions was the enzyme alcohol dehydrogenase, principally the enzyme from horse liver, but to some degree from other sources, such as the insect Drosophila melanogaster.[6] His work in this area concerned both "classical" steady-state kinetics, such as pH-dependence,[7] as well as study of transients in the mechanism.[8] In recognition of his contributions to the study of alcohol dehydrogenase Pettersson was invited to write a review on the topic in collaboration with Judith Klinman.[9]

Analysis of enzyme kinetic data

In parallel with his study of alcohol dehydrogenase, Pettersson developed methods in enzyme kinetics based on mathematical modelling and valid statistical analysis.[10][11] On the basis of this expertise he has written a text book (in Swedish) on enzyme kinetics.[12]

In a number of papers Pettersson argued against the interpretations of their kinetic data proposed by other authors, in relation for example to wheat-germ hexokinase[13] and hexokinase from rat liver.[14]

Multienzyme systems

Pettersson developed mathematical models of multi-enzyme systems, most notably the Calvin cycle,[15] and he entered into the controversy over whether direct transfer of the product of an enzyme-catalysed reaction to an enzyme of which it is the substrate (metabolite channelling) is a real phenomenon adequately supported by the experimental results claimed to demonstrate it.[16][17]

Global warming

After retirement, Pettersson has studied the question of global warming and has published a critical book against alarmists, in which the greenhouse effect is critically discussed from a scientific and kinetic perspective.[18]

References
  1. G. Pettersson, 1966. Studies on the biosynthesis of fungal toluquinones. PhD Thesis. Lund University. http://libris.kb.se/bib/1174668
  2. Pettersson, G. (1963). "Biosynthesis of fumigatin". Acta Chem. Scand. 17 (5): 1323–1329. doi:10.3891/Acta.Chem.Scand.17-1323.
  3. Pettersson, G. (1963). "Toluquinones from Aspergillus fumigatus". Acta Chem. Scand. 17 (6): 1771–1776. doi:10.3891/Acta.Chem.Scand.17-1771.
  4. Pettersson, G. (1965). "New phenolic metabolites from Gliocladium roseum". Acta Chem. Scand. 19 (2): 414–420. doi:10.3891/Acta.Chem.Scand.19-0414. PMID 14298279.
  5. Pettersson, G. (1966). "Hydroxyquinone–NADH oxidoreductase from Aspergillus fumigatus. II. Kinetic studies on the enzyme". Acta Chem. Scand. 20 (3): 666–674. doi:10.3891/acta.chem.scand.20-0666. PMID 4289501.
  6. McKinley-McKee, J. S.; Winberg, J. O.; Pettersson, G. (1991). "Mechanism of action of Drosophila melanogaster alcohol dehydrogenase". Biochem. Internat. 25 (5): 879–885. PMID 1804107.
  7. Gunnarsson, P. O.; Pettersson, G. (1974). "pH-Dependence of binding of Pt(CN)42-, AMP, and adenosine to horse liver alcohol dehydrogenase". FEBS Lett. 43 (3): 289–292. doi:10.1016/0014-5793(74)80663-0. PMID 4859594. S2CID 38196610.
  8. Kvassman, J; Pettersson, G. (1976). "Kinetic transients in reduction of aldehydes catalysed by liver alcohol dehydrogenase". Eur. J. Biochem. 69 (1): 279–287. doi:10.1111/j.1432-1033.1976.tb10884.x. PMID 186264.
  9. Pettersson, G.; Klinman, J. P. (1987). "Liver alcohol dehydrogenase". Crit. Rev. Biochem. 21 (4): 349–389. doi:10.3109/10409238609113616. PMID 3304836.
  10. Pettersson, G. (1972). "Kinetics of product inhibition in the ternary-complex mechanism for enzyme reactions involving two substrates". Acta Chem. Scand. 26 (10): 3935–3942. doi:10.3891/acta.chem.scand.26-3935. PMID 4631804.
  11. Pettersson, G. (1978). "Generalized theoretical treatment of transient-state kinetics of enzymic reaction systems far from equilibrium". Acta Chem. Scand. B. 32 (6): 437–446. doi:10.3891/Acta.Chem.Scand.32B-0437. PMID 706950.
  12. Pettersson, G. (1975). Enzymkinetik (in Swedish). Lund University.
  13. Pettersson, G. (1986). "Mechanistic origin of the kinetic cooperativity of hexokinase type L1 from wheat germ". Eur. J. Biochem. 154 (1): 167–170. doi:10.1111/J.1432-1033.1986.Tb09374.X. PMID 3943521.
  14. Pettersson, G. (1986). "Mechanistic origin of the sigmoidal rate behaviour of glucokinase". Biochem. J. 233 (2): 347–350. doi:10.1042/Bj2330347. PMC 1153034. PMID 3954739.
  15. Pettersson, G.; Ryde-Pettersson, U. (1988). "A mathematical-model of the Calvin photosynthesis cycle". Eur. J. Biochem. 175 (3): 661–672. doi:10.1111/j.1432-1033.1988.tb14242.x. PMID 3137030.
  16. Pettersson, G. (1991). "No convincing evidence is available for metabolite channelling between enzymes forming dynamic complexes". J. Theor. Biol. 152 (1): 65–69. doi:10.1016/S0022-5193(05)80512-0. PMID 1753770.
  17. Arias, W. M.; Pettersson, G. (1996). "Transient-state kinetic evidence against a channelled transfer of glyceraldehyde 3-phosphate from aldolase to glyceraldehyde-3-phosphate dehydrogenase". Eur. J. Biochem. 239 (3): 675–678. doi:10.1111/J.1432-1033.1996.0675U.X. PMID 8774712.
  18. Pettersson, G. (2012). Falskt Alarm: Klimatfrågan ur vetenskaplig aspekt (in Swedish). Archived from the original on 2017-12-16.
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