Gamma-glutamyl hydrolase

Gamma-glutamyl hydrolase is an enzyme[5][6][7][8] that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

Ghk.

Gamma-glutamyl hydrolase
Identifiers
EC no.3.4.19.9
CAS no.9074-87-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
GGH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGH, GH, gamma-glutamyl hydrolase, GATD10
External IDsOMIM: 601509 MGI: 1329035 HomoloGene: 2881 GeneCards: GGH
Orthologs
SpeciesHumanMouse
Entrez

8836

14590

Ensembl

ENSG00000137563

ENSMUSG00000073987

UniProt

Q92820

Q9Z0L8

RefSeq (mRNA)

NM_003878

NM_010281

RefSeq (protein)

NP_003869

NP_034411

Location (UCSC)Chr 8: 63.01 – 63.04 MbChr 4: 20.04 – 20.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.[7][9][10] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[10]

Nomenclature

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

  1. GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J (August 1993). "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta. 1164 (3): 227–35. doi:10.1016/0167-4838(93)90253-n. PMID 8343522.
  6. Yao R, Rhee MS, Galivan J (September 1995). "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48 (3): 505–11. PMID 7565632.
  7. Yao R, Schneider E, Ryan TJ, Galivan J (September 1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. doi:10.1073/pnas.93.19.10134. PMC 38349. PMID 8816764.
  8. Yao R, Nimec Z, Ryan TJ, Galivan J (April 1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. doi:10.1074/jbc.271.15.8525. PMID 8621474.
  9. Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R (Dec 1999). "Structural organization of the human gamma-glutamyl hydrolase gene". Gene. 238 (2): 463–70. doi:10.1016/S0378-1119(99)00362-5. PMID 10570974.
  10. "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)".

Further reading

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